College football odds, lines, bets, top predictions for Week 13, 2021: Model picks Oklahoma State, Oregon

SportsLine's advanced computer model has revealed its top college football picks and bets for rivalry week

By CBS Sports Staff

Nov 27, 2021 at 7:44 am ET • 3 min read

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The College Football Playoff committee could have a tough decision to make if No. 3 Alabama loses to No. 1 Georgia in the SEC title game next week. None of that will matter unless the Crimson Tide survives a trip to Auburn for the 2021 Iron Bowl on Saturday afternoon, though. The Tigers are without starting quarterback Bo Nix (ankle), which is a factor in why Alabama is a 20.5-point favorite in the latest Week 13 college football odds at Caesars Sportsbook. Georgia (-35) is expected to roll in its meeting against Georgia Tech during the Week 13 college football schedule.

Another game with playoff implications will take place on Saturday night when No. 6 Notre Dame travels to Stanford as a 19.5-point favorite. The Fighting Irish need to impress the committee with style points, so should you be laying the lumber with Notre Dame?Before making any Week 13 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 13 of the 2021 season on a 39-25 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 13 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 13 college football predictions

One of the top college football picks the model is recommending for Week 13: No. 7 Oklahoma State (-4.5) covers against No. 10 Oklahoma in the Bedlam Series 2021 rivalry matchup at 7:30 p.m. ET on Saturday. The Cowboys have a chance to sneak into the playoff if they can close the regular season with a win and add another quality victory in the Big 12 title game. They have won four straight games since suffering a 24-21 loss at Iowa State in late October. Oklahoma State has covered the spread in five consecutive games and is 4-1 ATS in its last five home games.

The Cowboys have the third-ranked defense in the country, allowing just 267.5 yards per game. They are facing an Oklahoma offense that put up just 14 points in its last road game, which came against Baylor on Nov. 13. SportsLine's model has Oklahoma State covering the spread in 60 percent of simulations, while the over (49.5) is hitting almost 60 percent of the time.

Another one of the college football predictions from the model: No.11 Oregon (-7) takes care of business against Oregon State in a 3:30 p.m. ET matchup on Saturday. The two-loss Ducks are no longer at the forefront of the College Football Playoff conversation, but they can still finish inside the top 10 this season. They had won five straight games prior to their loss at Utah last week. Oregon State has been atrocious on the road this season, losing four of its five games away from home.

SportsLine's model is not projecting a good day for Oregon State quarterback Chance Nolan, who is expected to throw for fewer than 200 yards and add an interception. The model is much higher on Oregon quarterback Anthony Brown, projecting 225 yards and two touchdowns for the Ducks' signal-caller. Oregon is covering the spread in almost 60 percent of simulations, while the under (60.5) is also cashing almost 60 percent of the time.

How to make Week 13 college football picks

The model has also made the call on who wins and covers in every other game on the Week 13 college football schedule, and it's also calling for a top College Football Playoff contender to get a huge scare from a big underdog. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.